JORO-SPIDER-TOXIN, [125I]
Lactoferrin
CAS: 112163-33-4
Molecular Formula: C27H47N7O6
JORO-SPIDER-TOXIN, [125I] - Names and Identifiers
JORO-SPIDER-TOXIN, [125I] - Physico-chemical Properties
| Molecular Formula | C27H47N7O6 |
| Molar Mass | 565.72 |
| Density | 1.195±0.06 g/cm3(Predicted) |
| Boling Point | 979.9±65.0 °C(Predicted) |
| Storage Condition | 2-8 ℃, stored in nitrogen |
| Use | Use contains 20mm PB and 50mM NaCl. Lactoferrin (LF), also known as lactoferrin (LTF), is a globular glycoprotein with a molecular weight of about 80KD. The structure of LF contains two highly homologous leaves, N and C leaves, each of which can reversibly bind two iron ions. LF is a member of the transferrin family that transports iron ions into cells and controls the concentration of free iron ions in the blood and secretions. At the same time, LF also has antibacterial, antiviral, anti-tumor and anti-allergic physiological effects, is an important part of the body's own immune system. |
JORO-SPIDER-TOXIN, [125I] - Risk and Safety
| Safety Description | 22 - Do not breathe dust. |
JORO-SPIDER-TOXIN, [125I] - Reference
| Reference Show more | 1. Wang Xuan, Hu Zhongqiu, Yuan Yahong, etc. Antibacterial effect of natural bacteriostats on Ruz's conjugating yeast [J]. Modern food science and technology, 2018, 34(10):100-108. 2. Cai Ning, Yang Qing, Jin Xin. Construction and formation mechanism of ginsenoside CK-lactoferrin Solid Dispersion [J]. Northwest Pharmaceutical Journal, 2020,35(05):696-701. 3. [IF = 7.514] Quanyang Li et al."Interaction between lactoferrin and whey proteins and its influence on the heat-induced gelation of whey proteins." Food Chem. 2018 Jun;252:92 4. [IF = 4.952] Quanyang Li et al."Protection effect of sodium alginate against heat-induced structural changes of lactoferrin molecules at neutral pH."Lwt Food Sci Technol. 2019 Jan;99:513 5. [IF=3.638] Zhengtao Zhao et al."Effect of lactoferrin on physicochemical properties and microstructure of pullulan-based edible films."J Sci Food Agr. 2019 Jun;99(8):4150-4157 6. [IF=7.514] Yating Zhang et al."Gallic acid liposomes decorated with lactoferrin: Characterization, in vitro digestion and antibacterial activity."Food Chem. 2019 Sep;293:315 7. [IF=7.46] Yaqin Zhang et al."A smartphone-integrated colorimetric sensor of total volatile basic nitrogen (TVB-N) based on Au@MnO2 core-shell nanocomposites incorporated into hydrogel and its application in fish spoilage monitoring."Sensor Actuat B- Chem. 2021 May;3 8. [IF=6.057] Lu Wang et al."Real-time monitoring of immunoglobulin G levels in milk using an ordered porous layer interferometric optical sensor."Talanta. 2022 Jan;237:122958 9. [IF=5.354] Yaxing Man et al."High voltage electrohydrodynamic atomization of bovine lactoferrin and its encapsulation behaviors in sodium alginate."J Food Eng. 2022 Mar;317:110842 10. [IF=5.115] Yueyao Jiang et al."The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route."Int J Nanomed. 2019; 14: 9217-9234 11. [IF=10.435] Hong Liping et al."A UCMPs@MIL-100 based thermo-sensitive molecularly imprinted fluorescence sensor for effective detection of β-lactoglobulin allergen in milk products."J Nanobiotechnol. 2022 Dec;20(1):1-12 |
JORO-SPIDER-TOXIN, [125I] - Introduction
& & Lactoferrin (lactoferrin,LF) is an important non-heme iron-binding glycoprotein in milk, and a monomeric glycoprotein with bactericidal activity in neutrophil granules. Its molecular weight is 80 kDa, which is mainly expressed and secreted by mammary epithelial cells.
Last Update：2022-10-16 17:30:47
JORO-SPIDER-TOXIN, [125I] - Nature
Open Data Unverified Data
| boiling point | 979.9±65.0 °C(Predicted) |
| density | 1.195±0.06 g/cm3(Predicted) |
| storage conditions | −20°C |
| acidity coefficient (pKa) | 9.53±0.35(Predicted) |
Last Update：2024-04-10 11:16:34
JORO-SPIDER-TOXIN, [125I] - Source
LF protein is widely found in exudates (milk, saliva, tears, nasal secretions), plasma, amniotic fluid, uterine secretions, urine and neutrophils, with colostrum having the highest content. Human and bovine lactoferrin amino acid sequences have 69% homology, so they have similar biological activities. However, the content of lactoferrin in milk is very low, and some formula milk will be additionally added with fortified (milk) lactoferrin to meet the baby's nutritional needs and promote its growth and development.
Last Update：2024-04-10 22:29:15
JORO-SPIDER-TOXIN, [125I] - Efficacy and Function
Open Data Unverified Data
1. enhance body resistance: lactoferrin (LF) plays an important role in the body's defense system. Studies have shown that LF is a natural protein in animal colostrum. It is a multifunctional protein with a broad-spectrum antibacterial and antiviral infection effects. It can regulate the balance of iron in the body; regulate the body's immune function, enhance the body's disease resistance; inhibit the body The role of tumor cells; it can work together with a variety of antibiotics and antifungal agents to treat diseases more effectively.
2. Participate in iron metabolism, promote the growth of probiotics in the intestine, and regulate the transmission of iron: Treating gastroenteritis is one of the most important functions of lactoferrin. The inhibitory effect of LF on intestinal pathogens is mainly achieved through two ways: inhibiting the growth of cell bacteria; destroying the function of virulence factors on the surface of bacteria to weaken the ability of virus adhesion or invasion of mammalian cells.
3. Antibacterial and antiviral, regulate immune function, antioxidant effect: Under normal circumstances, the freedom in human cells is basically in a state of balance. When free radicals increase abnormally, the body's antioxidant capacity decreases, resulting in excess free radicals., It will cause peroxidation, leading to fatigue and virus damage. LF is a multifunctional protein, which not only participates in iron transport, but also has powerful biological functions such as broad-spectrum antibacterial, antioxidant, anti-cancer, and immune system regulation. Therefore, the protective effect of lactoferrin on infants may be achieved by preventing the adsorption of intestinal pathogens on the inner wall of the intestine. Several recent clinical trials in children have yielded similar results.
On March 30, 2012, China's "National Food Safety Standard-Food Nutrition Enhancer Application Standard" listed lactoferrin in the GB14880-2012 and recognized it as a food nutrition fortifier. Lactoferrin is also a unique ingredient in breast milk, which can inhibit viruses and harmful bacteria.
Last Update：2024-04-10 11:16:54
JORO-SPIDER-TOXIN, [125I] - Content
lactoferrin is a macromolecule with a variety of biological activities, but its content is very small. the contents of human colostrum and normal milk are 0.5 mg/100 ml and 0.17 mg/100 ml respectively. The contents of bovine colostrum and normal milk are 0.1 mg/100 ml and 0.01 mg/100 ml respectively. The lactoferrin in human breast milk is the highest, ranging from 1g/L to 7g/L, which is much higher than the lactoferrin content in milk (0.15g/L). In breast milk, colostrum has the highest concentration of lactoferrin (about 6g/l), followed by transitional milk (2-5 days postpartum to 10-14 days postpartum; about 3.7g/l) and mature milk (about 1.5g/l). In the natural state, lactoferrin is mostly iron unsaturated, so it has a strong ability to bind, transfer and release iron.
Last Update：2024-04-10 22:29:15
JORO-SPIDER-TOXIN, [125I] - Application
Open Data Unverified Data
Lactoferrin has antibacterial, antioxidant, anti-cancer and other biological activities, and has applications in infant formula, cosmetics and other products
Last Update：2024-04-10 11:18:00
JORO-SPIDER-TOXIN, [125I] - Introduction
lactoferrin (LF) is a 75-80 kDa non-heme iron-binding glycoprotein. it was produced about 0.125 billion years ago when placenta animals and marsupials differentiated. it is classified into the transferrin family due to its high homology with transferrin, and is the youngest member of the transferrin family. Studies have found that LF protein has a variety of biological functions, including broad-spectrum antibacterial, antiviral, and anti-tumor effects, and is related to many important physiological processes in the body, such as regulating iron balance in the body, regulating bone marrow cell production, and promoting cell growth, Regulate the body's immune function, enhance the body's disease resistance, anti-hypertensive activity, and cooperate with a variety of antibiotics and antifungal agents.
Last Update：2024-04-09 01:59:49
JORO-SPIDER-TOXIN, [125I] - Broad-spectrum antibacterial effect
Gram-negative and positive bacteria inhibit Gram. First of all, lactoferrin has high iron, and bacteria lose growth in basic nutrient iron. In addition, the protein increases the permeability of the bacterial cell membrane through the amino non-terminal strong cation binding region, and the bacterial lipopolysaccharide exudes the outer membrane directly to sterilize.
Lactoferrin and lactoferrin peptide can inhibit Trichophyton, and Trichophyton is the pathogenic fungus of many skin diseases, such as skin ringworm. It can also kill Candida albicans, a diploid fungus (a form of yeast) that causes conditional oral and reproductive tract infections in humans.
Fluconazole has been used to kill Candida albicans for many years, and this fungus has also developed resistance to fluconazole. However, if lactoferrin is used in combination with fluconazole (the protein is first used and then fluconazole is incubated with Candida in sequence), it will be able to kill the already resistant Candida. In addition, it was found that the antifungal activity of lactoferrin peptide is higher than that of lactoferrin, especially the synthetic peptide (synthetic peptide) lactoferrin peptide shows greater antifungal activity than natural lactoferrin (native lactoferricin).
Last Update：2024-04-09 21:31:46
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